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I have been on Uloric (40mg) for 3 weeks now. I have been testing my Uric Acid level for 4 months prior to taken Uloric once/week via home tester….always btw. 6-10. Sometimes if I had no beer that week, and no seafood I could get below 6.
The day I took my 1st Uloric pill I was 9.8, 1 week later 6.0, 2 weeks in 3.8, 3 weeks in 3.4….I have also increased eating of seafood and beer drinking during this time, two things that would always spike me close to 9-10. I have been eating seafood 2-3 days a week, and 2 beers/night and still some great results.
I'll keep monitoring and post results here, but for my lifestyle this seems to be working, but I know early days. I have had 8 gout episodes in last 3 years, so not a lot of attacks compare to many othere here. I'm 47 and in very good shape working out 4-5 days/week, not overweight, and do homebrew so I am hoping this keeps my UA level in check.
Hope others see as quick/good as or better results than me.
dp,
You're doing well and I'm happy you are getting good results with the 40 mg. dosage. Is your insurance covering your costs pretty well?
Eight episodes in 3 years is nothing to sneeze at…that's a lot of pain. It's probably even more attacks than I had before I started treatment. (Since it's been 15 years acute attack free I wonder if I can throw away the crutches. But we all know Murphy's law.)
Here's allopurinol:
and here's the xanthine (the major dietary purine) that it mimics:
See how devilishly clever the drug is? Notice only that single misplaced nitrogen. You can ignore the attached hydrogens and that double bonded oxygen…it readily picks up an H to form an OH. So along comes a xanthine oxidase enzyme and it gets confused and thus ignores a lot of the xanthine…whiich you pee out.
AP certainly looks simpler than Uloric from above pics.
Is the oxidizing effects of AP a possible reason for the formation of free radicals- and hence negative side effects?
I know Zip, you're not keen on this idea, but free radicals do exist and there's very little on AP side effects 'in depth' floating around, at least from what I've seen. It's difficult enough trying to understand the 'up-sides' alone, for us non Chemists!
No, No….
Allopurinol is OXIDIZED to oxypurinol, thus allopurinol is a REDUCING agent and thus it is an “anti-oxidant.” Oxypurinol is FURTHER oxidized and thus also an “antioxidant.”
THe quotes are to illusrtate my feeling that antioxidant is merely a fashionable silly buzz word. ALL FOODS are anti-oxidants, reducing agents, that use up oxidizers for their metabolism and create energy.
So for your next ultra high dose of antioxidants have an 18 inch pizza.
“Free radical” is the buzzword for oxidants doiing their work…nascent oxygen oxidizing food and making the energy of LIFE. ALL bodily chemical reaction occur using temporary “free radicals.” To go further, O2 is inert…only when it breaks into individuall [O] can it oxidize…and release energy. ANd [O] is the ultimate and consummate free radical, called nascent oxygen…the only way it can do its work.
Let me go simple (but not disparaging.) Wood, coal and petroleum are the ultimate antioxidants…they all use up oxidizers, primarily oxygen to burn them.
Can you see how in a universe of REDOX reactions (that's what they're called) there is nothing unuoque about antioxidants except for people PEDDLING the concept. They are in reality anything that can be burned.
I'm not being glib…just real.
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